Background: The characteristics of 90Y, suitable for therapy, are demoted by the lack of ã-emission. Alternative methods, using analogues labelled with 111In or 86Y, are generally applied to image 90Y-conjugates, with some inevitable drawbacks. New generation SPECT/CT image systems offer improved Bremsstrahlung images. Intent of this brief communication is to show that high quality 90Y-Bremsstrahlung SPECT-CT images can be obtained, allowing to evaluate the biodistribution of pure â-emitter therapeutical agents, also during the course of therapy.
Methods: The hybrid system Siemens Symbia-T2 was used for the acquisition of a patient administered with 1.7 GBq of 90Y-DOTATATE. The following parameters were set for SPECT: 80(50%) keV and 120(30%) keV energy windows medium energy collimators 128x128 matrix, 64 projections (40s/step). Low-dose CT was acquired (80mAs) for attenuation correction. Images were reconstructed with the OSEM 3D-Fast algorithm.
Results: Post-therapy SPECT-CT 90Y-Bremsstrahlung images of a patient undergoing receptor peptide radionuclide therapy are presented. 90Y-Bremsstrahlung images obtained are suitable for tumour and normal organ dosimetry, offering detailed information on biodistribution, comparable to 111In-diagnostic images.
Conclusions: The improvement on Bremsstrahlung images allows to address diagnostic examinations to patient recruitment and to restrict ample dosimetry evaluation only to treated patients. This could avoid the need of a different radionuclide or isotope to mimic therapy. The clinical impact might be notable, being dosimetry and toxicity information essential in radionuclide therapy especially in patients with risk factors.
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