Semin Liver Dis 2010; 30: 087-098DOI: 10.1055/s-0030-1247135ABSTRACTThe etiology of liver cancer is well known, but despite recent progress in the application of molecular techniques for the analysis of the development of these tumors, we still lack precise knowledge about pathogenesis of hepatocellular carcinoma (HCC). Animal models can provide essential knowledge about HCC pathogenesis, particularly if they mimic the tissue environment in which human tumors develop. The synergism between studies in animal models and human tumors is strengthened by using comparative genomic analysis to identify genes and pathways that are critical for both mouse and human oncogenesis. In this article, the authors discuss some selective examples of constitutive, conditional, and inducible models of HCC dev…

Further information:

Article source

Related posts:

1. Identification of Novel Oncogenes and Tumor Suppressors in Hepatocellular Carcinoma
2. Association between C282Y and H63D mutations of the HFE gene with hepatocellular carcinoma in European populations: a meta-analysis
3. Molecular Classification and Novel Targets in Hepatocellular Carcinoma: Recent Advancements
4. Hepatocellular Carcinoma: Epidemiology, Surveillance, and Diagnosis
5. Coronin-1C is a novel biomarker for hepatocellular carcinoma invasive progression identified by proteomics analysis and clinical validation