Aims: Although a previous study found high risk of breast cancer in mothers of children with soft tissue sarcomas, breast cancer risks in mothers of other childhood cancer largely remain unknown. The etiology is not fully understood. The present study explored this excess by varying type of childhood solid cancer and formulated a hypothesis.

Methods: Mothers of 2668 children with solid tumours included in the Manchester Children’s Tumour Registry, 1954-1996 were traced and followed up to 31st December 2000 through the UK National Health Service Central Register. Standardised Incidence Ratio(SIR), P-values and 95% confidence intervals were calculated from age and calendar year-specific female breast cancer incidence rates for England and Wales.

Results: There was a significant excess of breast cancer in mothers overall(SIR=1.3,95%CI=1.0-1.5) mainly due to mothers of children with rhabdomyosarcoma (RMS) (SIR=2.2, 95%CI=1.0-4.0), skin cancer(SIR=7.9, 95%CI=2.9-17.1), and central nervous system tumours(SIR=1.2, 95%CI=0.9-1.8). Maternal breast cancer risk was associated with late age at birth of the index child and male sex and young age at diagnosis in the index child. Risk was highest in the 10 years following the birth of the index. The pattern was seen most strongly in mothers of children with embryonal RMS.

Conclusion: There are excesses of breast cancer in mothers of children with solid tumours in general and specifically in RMS, skin and CNS. There appears to be a temporal relationship between certain tumours in children and breast cancer in their mothers, suggesting a origin of their respective pregnancy. We propose a mother-fetal
interaction mechanism to explain this association.

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