Abstract: 3D point distribution model (PDM) of subcortical structures can be applied in medical image analysis by providing priori-knowledge. However, accurate shape representation and point correspondence are still challenging for building 3D PDM. This paper presents a novel framework for the automated construction of 3D PDMs from a set of segmented volumetric images. First, a template shape is generated according to the spatial overlap. Then the corresponding landmarks among shapes are automatically identified by a novel hierarchical global-to-local approach, which combines iterative closest point based global registration and active surface model based local deformation to transform the template shape to all other shapes. Finally, a 3D PDM is constructed. Experiment results on four subc…
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